霍海波,女,甘肃天水人,博士,讲师。主要研究方向:(1)豆科植物—根瘤菌共生互作分子机制研究;(2)小分子化合物及其衍生物的抑菌/抗癌活性研究。研究成果以第一作者(或并列第一作者)发表在《Plant Cell Environment》、《Tree Physiology》、《European Journal of Medicinal Chemistry》、《Bioorganic & Medicinal Chemistry》等期刊。 主持山西省高等学校科技创新计划项目1项(2022L510);主持山西省基础研究计划(自由探索类)项目1项。 一、教育科研经历 2006.09—2010.06 兰州理工大学 生物工程专业,获工学学士学位。 2014.09—2017.06 西北农林科技大学 微生物学专业,获理学硕士学位。 2017.09—2021.12 西北农林科技大学 微生物学专业,获理学博士学位。 二、主要学术成果 [1] Huo H, Zong L, Liu Y, Chen W, Chen J, Wei G. Rhizobial HmuSpSym as a heme-binding factor is required for optimal symbiosis between Mesorhizobium amorphae CCNWGS0123 and Robinia pseudoacacia. Plant Cell Environment. 2022. 45:2191-2210. [2] Huo H, Wang X, Liu Y, Chen J, Wei G. A Nod factor- and type III secretion system-dependent manner for Robinia pseudoacacia to establish symbiosis with Mesorhizobium amorphae CCNWGS0123. Tree Physiology. 2021, 41:817-835. [3] Wang X, Huo H#, Luo Y, Liu D, Zhao L, Zong L, Chou M, Chen J, Wei G. Type III secretion systems impact Mesorhizobium amorphae CCNWGS0123 compatibility with Robinia pseudoacacia. Tree Physiology. 2019, 39:1533-1550. [4] Huo H, Li G, Shi B, Li J. Recent advances on synthesis and biological activities of C-17 aza-heterocycle derived steroids, Bioorganic & Medicinal Chemistry, 2022, 69: 116882 [5] Huo H, Jiang W, Sun F, Li J, Shi B. Synthesis and biological evaluation of novel steroidal pyrazole amides as highly potent anticancer agents. Steroids. 2021, 176:108931. [6] Li J, Huo H#, Guo R, Liu B, Li L, Dan W, Xiao X, Zhang J, Shi B. Facile and efficient access to Androsten-17-(1’,3’,4’)-pyrazoles and Androst-17β-(1’,3’,4’)-pyrazoles via Vilsmeier reagents, and their antiproliferative activity evaluation in vitro, European Journal of Medicinal Chemistry, 2017, 130:1-14. |